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It is crucial to remember that this formulation should not be applied to broken or irritated skin

A separate Phase 2 trial also published in The New England Journal of Medicine in 2023 evaluated retatrutide in adults with type 2 diabetes, reporting meaningful reductions in HbA1c alongside weight loss, with hypoglycaemia rates that were low in the absence of insulin or sulfonylurea co-administration

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Compounded semaglutide uses the same active ingredient but may differ in formulation, concentration, and added compounds