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Here's what that looks like: The Retatrutide Escalation Protocol (Phase 2 Trial Structure) Weeks 1-4: 2 mg subcutaneous injection, once weekly Weeks 5-8: 4 mg once weekly Weeks 9-12: 8 mg once weekly Weeks 13-16: 12 mg once weekly (highest dose arm) Week 17+: Maintenance at the highest tolerated dose In the Phase 2 trial published in The New England Journal of Medicine , participants in the highest dose group (12 mg) lost a mean of 24.2% of body weight at 48 weeks

The headliner was retatrutide, a triple-agonist that targets GLP-1, GIP, and glucagon receptors and the numbers were unlike anything previously reported in late-stage obesity trials

Likewise, chemotherapy drugs or biologics that weaken immune surveillance can create a similar imbalance