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When activated by GLP-1 agonists, these receptors enhance gut motility and increase intestinal fluid secretion, accelerating stool transit and water content
In 2025, Mounjaro led global GLP-1 drug sales, followed by Ozempic, Zepbound, and Wegovy
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[3] Hypothalamic-Pituitary-Adrenal (HPA) Axis Modulation : DSIP has been observed to attenuate stress-induced corticotropin-releasing hormone (CRH) activity, potentially reducing systemic cortisol release
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