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Two recent meta-analyses of eight cardiovascular outcome trials (CVOTs) and several other meta-analyses that included non-CVOT studies estimated the reduction in cardiovascular mortality varied between 12 and 15% (Zheng et al., 2018

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In breast cancer, transcription factor AP-2 gamma (TFAP2C) is an important transcription factor that regulates estrogen receptor-alpha (ER) and c-ErbB2/HER2 (Her2), which are involved in the establishment of the gene expression pattern observed in different clinical phenotypes of breast cancer [79, 80]