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Hum Brain Mapp

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The integrated PK-PD findings, including nonlinear exposure, target tissue accumulation, and disruption of L-carnitine homeostasis, collectively elucidate mildronates mechanism of action through energy substrate depletion, as well as its intrinsic efficacy-toxicity duality

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Claims for Limited Use (LU) drugs will be reimbursed under the Ontario Drug Benefit (ODB) program only when prescribed for an ODB-eligible recipient (including OHIP+ beneficiaries) in accordance with the criteria outlined for each product and accompanied by a valid, fully completed prescription with the appropriate LU documentation (RFU code)

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