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A short in vitro exposure in adipocytes is not equivalent to chronic systemic exposure in an animal model, and a model-specific biochemical response is not equivalent to a broad toxicological conclusion

Although selenium is a necessary nutrient, the body has a relatively low rate of excess selenium excretion because evolutionarily selenium is a fairly uncommon nutrient to encounter

Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum

The effects were observed regardless of the time and mode of administration