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This triple mechanism of action distinguishes retatrutide from currently approved medicines such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist)

Other GLP-1s may also have protective effects on the brain: Liraglutide: Early studies, including data presented at the Alzheimer's Association International Conference (AAIC), suggest it may lower the risk of dementia by improving blood flow and reducing inflammation

13098_2025_1877_MOESM1_ESM.docx (download DOCX Supplementary Material 1 Supplementary Table 1: PRISMA 2020 Checklist, Supplementary Table 2 Search strategy, Supplementary Table 3 List of Exclusion Reports, Supplementary Table 3: Details of adverse reactions, Supplementary Tabel 4: GRADE Summary of Skeletal Muscle Mass Changes in Type 2 Diabetes with Sarcopenia Receiving GLP-1 Receptor Agonist: Systematic Review and Meta-analysis, Supplementary Table 5 List of Exclusion Reports, Supplementary Table 6 Basic characteristics of GLP-1 Receptor Agonist preparations

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