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Significant nausea or stomach upset is uncommon on the first day because treatment begins with a low introductory dose
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Schwarzschild MA, Macklin EA, Bakshi R, et al
Odds of gastrointestinal events were similar between tirzepatide and GLP-1 RAs, except for diarrhoea with tirzepatide 10 mg (OR 1.51 [95% CI 1.07, 2.15], I 2 0%) (Table 2)
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