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Subanalyses of EXSCEL, SUSTAIN-6 and PIONEER-6 trials suggested that patients with HF may not necessarily benefit from GLP-1RA therapy
The peptide has gained popularity among athletes and the general public for injury recovery, leading the World Anti-Doping Agency to ban it in 2022
The question, as with combining GLP-1 and GIP receptor activity, is whether adding glucagon receptor activity to GLP-1 receptor activity exceeds the glycaemic lowering and weight loss achieved with a GLP-1 RA alone (Ambury et al, 2018
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