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It is also emphasized that glutamine metabolism heterogeneity and adaptability become one of the main reasons for drug resistance in tumor patients, so we explore the mechanism of cancer cells utilizing glutamine metabolism-related branched pathways as well as bypassing glutamine metabolism to participate in the occurrence of drug resistance, which provides a new diagnostic and therapeutic idea for the further clinical development of glutamine metabolism-related antitumor drugs

10.1016/j.neubiorev.2018.05.005 56 JacksonL.EldahshanW.FaganS

The evening dose works best if administered at least two hours after your last meal, ensuring reduced insulin interference