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Gradual dose escalation, starting with a lower dose and slowly increasing over several weeks, is recommended to help the body adapt and minimize potential gastrointestinal side effects like nausea and vomiting, which are common at higher doses
Its common to experience some mild, temporary side effects at the injection site
[4] Receptor Grade IGF-1 LR3 and Insulin-Like Growth Factor Receptor Interactions Naturally produced IGF-1 hormones interact with at least two cell surface receptors: the IGF-1 receptor (IGF-1R) and the insulin receptor
NICE guidance (NG28) recommends considering dose reductions of insulin or sulfonylureas when initiating a GLP-1 receptor agonist to mitigate this risk
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