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During the initial weeks of retatrutide treatment, the primary experience for most participants in clinical trials was gastrointestinal adjustment rather than dramatic weight loss

Pregnant or breastfeeding women are typically advised against use due to insufficient research

Important safety information includes a boxed warning for risk of thyroid C-cell tumors, with contraindications in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

This results in a decrease in appetite and changes in taste, and causes users to change the way they eat