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Further ECD-focused 3D classification revealed an alternate CT-like conformation induced by Cagri when bound to the CTR, however, this conformation was only observed in 8% of the particles (Fig
These deleterious signaling cascades converge on mitochondria, where membrane-potential loss, electron-transport dysfunction, and mitochondrial permeability transition pore opening (mPTP) promote cytochrome c release and cell death [2,3,4,5,6,7,8]
Still workable but tighter
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