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Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement
Many patients begin with a loading phase, which typically involves several injections per week over two to four weeks
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That could mean alternative dosing schedules, transitioning to lower-cost drugs, or combining medications with intensive behavioral interventions and medical nutrition therapy. He also points out that since the team completed their analysis, policymakers have clarified that the proposed $245 Medicare price is inclusive of a $50 monthly copay
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