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Additionally, lifestyle factors like not drinking enough water, low fiber intake, and lack of physical activity can add to the risk of constipation while on semaglutide

You should not take semaglutide or tirzepatide if you have: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN2) History of pancreatitis or gallbladder disease Severe kidney or liver disease Diabetic retinopathy (in some cases) Severe gastrointestinal disease Pregnancy or breastfeeding This is not a complete list of contraindications

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A Practical Perspective GLP-1 medications represent an important advance in treating metabolic disease because they can meaningfully reduce appetite and help many patients achieve weight loss that was previously difficult to sustain