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Furthermore, elements including NF-B, Toll-like receptors, and bone bridging proteins significantly affect insulin resistance, all of which are regulated by epigenetic mechanisms (Karina et al., 2021)
Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline
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