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A systematic review and meta-analysis based on a total of 16 studies archived in the PubMed and Embase databases that assessed pregnancy outcomes in 4,564,798 women revealed that mothers who used SSRIs had an odds ratio (OR) of 1.22 (95% confidence interval (CI): 1.121.33) for congenital heart disease (CHD) in their fetuses, with an increased risk of approximately 22% and an OR of 1.53 (95% CI: 1.251.88) for paroxetine, an increased risk of approximately 53% and an OR of 1.28 (95% CI: 1.011.62) for fluoxetine, and an increased risk of approximately 28% and an OR of 1.28 (95% CI: 1.141.45) (De Vries et al., 2021)

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Per-component dose ranges in published preclinical research differ across the two compounds