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That is about double what we see with tirzepatide, nearly three times better than semaglutide and 4mmHg better than the CagriSema trials
Second, the gut can act independently as if it has a mind of its own: due to local reflex circuits, the ENS is capable of functioning with and without input from the central nervous system (Fleming II et al., 2020)
Its working in the gastrointestinal tract, its working in the brain and its working in the pancreas
The reduced food intake can make this dip more noticeable initially
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