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(1) The DRI part stands for D-retro-inverso, suggesting it was synthesized using D-amino acids and arranged in a reversed order compared with the original L-peptide fragment from FOXO4
This leads to a significant increase in synaptogenesis (the formation of new neural connections) and neuroplasticity, contributing to improved memory and cognitive function
Strikingly, substitution of proline at position 3 (P3A) abolished binding, yielding a KD = 56.7 (Fig
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10.3390/biomedicines3010001 6 BleauA
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