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Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven Medulloblastoma
and hydrophilic factor ( Hy ), which reflects the ability of a molecule to interact with water through polar interactions such as hydrogen bonds or dipole interactions, calculated using alvaDesc software (Alvascience, Lecco, Italy)
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We believe, targeting CD20 with the CAR-T approach, and with simultaneous hit on BCMA, may provide a deeper strike and in broader autoimmune indications
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